Variant calling finds the differences between a sequenced genome and a reference SNPs, insertions, deletions and structural changes. These are the genetic basis of inherited disease, cancer mutations and population diversity. Every downstream analysis starts here. Get this wrong and everything built on top of it is unreliable.

Germline variants are inherited present in every cell and passed to offspring. Somatic variants arise after conception, typically in tumor cells, found by comparing tumor and normal tissue from the same patient. The tools used for each are completely different. GenomeBeans handles both in the same automated pipeline.

Yes. Both whole genome sequencing and whole exome sequencing inputs are fully supported. Upload your raw FASTQ files and the platform automatically selects the right alignment and variant calling parameters. No manual configuration needed.

Variants are annotated using multiple reference databases including dbNSFP, ClinVar, dbSNP, dbscSNV, gnomAD, and the 1000 Genomes Project. Together, these resources provide information on known variants, population allele frequencies, clinical significance, functional predictions, and splice-site impact. This comprehensive annotation framework helps prioritize potentially pathogenic variants and distinguish rare disease-associated variants from common benign polymorphisms.

A fully annotated VCF file, hard-filtered SNP and indel tables, functional impact annotations, population frequency data and IGV visualizations all packed into one interactive HTML report you can open in any browser and share instantly.

100% private. You own everything you upload. It is never shared. Never sold. Results are securely archived for 90 days then permanently deleted from our servers. No exceptions. No fine print.